Effects of Application of Chlorpyrifos Ethyl and Rose Water on Rat Pancreas

Abstract

This study was conducted to detect preventive effects of rose water against toxicological effects of chlorpyrifos-ethyl. Group I was control group, group II was chlorpyrifos-ethyl (CPE) group (0.3 mg/kg/day), group III was water solution of rose extract (WR) group (100 mg/kg/day) while group IV was water solution of rose extract + chlorpyrifos-ethyl group (WR+CPE). The rats were sacrificed after fifteen days of experiment to collect blood samples. The results showed that comparing to the CPE group, there was a significant (p<0.001) decrease in the malondialdehyde (MDA) and total oxidant capacity (TOC) levels and a significant (p<0.001) increase in the total antioxidant capacity (TAC) and insulin levels in the CPE+GS group. Between the control and WR groups, insulin, WBC, catalase (CAT), lipase and amylase levels were significantly (p<0.001) higher, while TOC and OSI levels were significantly (p<0.001) lower in the WR group. The highest OSI levels were determined in the CPE group followed by CPE+RW (1.02 µmol H2O2 equ. /L), control (0.93 µmol H2O2 equ. /L) and RW (0.87 µmol H2O2 equ. /L) groups. In conclusion, it can be said that WR showed positive effects on the enzymes of pancreas and hematological parameters in rats, and it reduced in toxic effects of CPE.