CURCUMIN PROTECTION FROM REPRODUCTIVE TOXICITY CAUSED BY TRAMADOL IN MALE RABBITS.

Abstract

Curcumin may be a shining yellow chemical created by plants of the Curcuma longa species. It is the vital curcuminoid of turmeric (Curcuma longa), a part of the ginger family, Zingiberaceae. It is sold as a homegrown supplement, beauty care products ingredient, food flavoring, and nourishment coloring. Tramadol may be a manufactured centrally dynamic opioid pain relieving utilized to oversee direct to extreme pain. It has double component of activity. It works by official to µ-opioid receptors within the brain and spinal line. Hence, the display explore was attempted to decide the viability of curcumin in lightening the harmfulness of tramadol on body weight, regenerative execution and testesteron of male rabbits. Animals were alloted to 1 of 4 bunches: control; 50mg tramadol/kg bw; 15 mg curcumin /kg bw; tramadol (50 mg/kg bw) also curcumin (15 mg/kg bw), separately. Comes about appeared that live body weight (LBW), testicles weight (RTW), and serum testosterone were significantly diminished (P<0.05) by treatment with tramadol. tramadol treatment moreover diminished (P<0.05) ejaculate volume, sperm concentration, add up to sperm yield, sperm motility list, and semen introductory fructose concentration. The negative impacts of tramadol on semen characteristics were dose-dependent. Treatment with curcumin expanded (P<0.05) LBW, TW, serum testosterone concentration, moved forward semen characteristics and reduced the negative impacts of tramadol. tramadol treatment expanded (P<0.05) the numbers of irregular and dead sperms in a dose-dependent way. Treatment with curcumin reduced the negative impacts of tramadol amid treatment. Comes about illustrated the advantageous impacts of curcumin in lessening the negative impacts of tramadol on generation and generation of male rabbits.