HEMATOLOGICAL PARAMETERS AND BLOOD SMEAR EFFECTS OF TRAMADOL ON MALE RABBITS

Abstract

Analgesics are a bunch of drugs that act totally different ways on the central apprehensive framework to absense of pain and alleviation from torment. It is in this manner imperative to ponder the impacts of organization these analgesics to decide the side impacts for them utilize. Hence we decided to study the hematological effects of tramadol on male rabbits. Tenth rabbits were arbitrarily partitioned into two break even with bunches (each bunch five rabbits). The primary gather was utilized as a control. The moment gather was utilized to consider the impact of tramadol (50 mg/kg body weight) for six weeks. Hemoglobin (Hb) substance, ruddy blood cells (RBCs) number and hematocrit (Hct) esteem diminished, whereas white blood cells (WBCs) and platelets tallies expanded after tramadol organization. Verbal organization of tramadol induced significant changes within the morphology of erythrocytes. In rabbit treated with tramadol the cells were appeared change in typical shape from star molded to sickle cells. The ponder appeared the destructive impacts of tramadol on the hematological parameters and blood spread on mail rabbits.