Biosynthesis of Iron Oxid Nanoparticles Coated with Folic Acid by Bacillus Megaterium
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Abstract
Background: Magnetic nanoparticles have stability in different physiological conditions, suitable biocompatibility, high chemical stability, low toxicity, etc. and can be considered as novel nanocarriers in diagnostic and drug delivery systems.
Purpose: This study was biosynthesis of iron oxide nanoparticles coated with folic acid by Bacillus megaterium.
Methods: In experimental part, nanoparticles were biosynthesis with Bacillus megaterium PTCC1656 suspension in the presence of folic acid and then characterized.
Results: In the experimental part, with the results obtained from DLS, we found that the particle size distribution is relatively narrow around 110 nm, and most of the particles are between 30 and 200 nm. According to the obtained zeta potential, the biosynthesized magnetite nanoparticles are stable. According to the XRD results, the nanoparticles have a cubic crystal structure and the space group was Fd-3m form. The examination of FTIR showed us the specific bands of folic acid indicated that this molecule was placed on the surface of nanoparticles and the coating was done well.
Keywords: Folic asid, Iron oxide, Biosynthesis, Bacillus megaterium, Nanoparticle
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