Adenosine Receptors in Alzheimer’s Disease: A Functional Analysis

Abstract

Alzheimer’s disease, characterized by a progressive decline in cognitive functions, is one of the most prevalent neurological disorders among the elderly. Adenosine, a purine nucleoside abundant in the central nervous system, serves as a neuroprotective agent. Dysfunction of adenosine receptors plays a critical role in the pathology of Alzheimer’s disease and their balance is essential for treating brain disorders. Recently, the role of these receptors in inflammation and apoptosis, key contributors to Alzheimer’s disease, has garnered significant attention. This study examines brain development during the embryonic period, identifies brain regions implicated in Alzheimer’s disease, and specifically investigates the role of adenosine receptors in this condition. The research employs a descriptive-analytical methodology utilizing library resources.                                                                                  

Keywords: Alzheimer's disease, adenosine, A1 receptor, A2A receptor.